Friday, April 26, 2019

Acebutolol - a beta-blocker

Acebutolol belongs to the group of medicines known as beta-blockers. It works on the heart and blood vessels.

Acebutolol slows down the activity of your heart by stopping messages sent by some nerves to your heart. It does this by blocking tiny areas (called beta-adrenergic receptors) where the messages are received by your heart. As a result, your heart beats more slowly and with less force. This allows the pressure of blood within your blood vessels to be reduced if you have high blood pressure (hypertension), and helps to prevent abnormally fast and uneven heartbeats if you have a heart rhythm disorder (arrhythmia). Because your heart is using less energy, it helps to reduce chest pain if you have angina.

Before taking acebutolol
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking acebutolol it is important that your doctor knows:

If you are pregnant, trying for a baby or breastfeeding.
If you have any problems with the way your kidneys work.
If you have asthma or any other breathing disorder.
If you have diabetes.
If you have been told you have a slow heartbeat or a slow and irregular heartbeat (heart block).
If you have been told you have chest pain caused by spasms of your heart's blood vessels, a condition called Prinzmetal's angina.
If you have low blood pressure, heart failure, or poor circulation.
If you have a skin problem called psoriasis.
If you have a condition causing muscle weakness, called myasthenia gravis.
If you have a tumour on your adrenal gland, called phaeochromocytoma.
If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.
If you have ever had an allergic reaction to a medicine, or if you have ever had any other serious allergic reaction.
How to take acebutolol
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about acebutolol and will provide you with a full list of the side-effects which you may experience from taking it.
Your doctor will tell you what dose is right for you, and this information will be printed on the label of the pack to remind you. Take acebutolol exactly as your doctor tells you to. You may be asked to take a dose once, twice or three times a day.
Swallow the tablet/capsule with a drink of water. Acebutolol will work the same whether you take your doses before or after food; however, taking your doses after a meal will help to reduce the risk of stomach upset. Try to take your doses of acebutolol at the same times each day. This will help you to remember to take them regularly.
Acebutolol is available in several different strengths. When starting your treatment your doctor may give you a small dose at first and then gradually increase it. Each time you collect a fresh supply, it's a good idea to check the strength on the packet to make sure they are what you are expecting.
If you forget to take a dose, take it as soon as you remember. If when you remember, it is nearly time for your next dose then take your next dose when it is due but leave out the missed dose. Do not take two doses together to make up for a forgotten dose.
Getting the most from your treatment
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
Treatment with acebutolol can often be long-term. Continue to take the tablets/capsules unless your doctor tells you to stop. Stopping treatment suddenly can cause problems in some people, so your doctor may want you to reduce your dose gradually if this becomes necessary.
If you are due to have an operation or dental treatment, it is important to tell the person carrying out the treatment that you are taking a beta-blocker. This is because some anaesthetics may increase the risk of unwanted effects.
If you drink alcohol, ask your doctor for advice. Alcohol will add to the blood pressure-lowering effect of acebutolol and so may not be advisable for you.
If you have diabetes, acebutolol can mask the symptoms of low blood sugar. Your doctor will advise you about this.
If you buy any medicines, check with a pharmacist that they are suitable for you to take. Some medicines (including some painkillers, cold and flu remedies) may not be.
Your doctor may give you dietary and lifestyle advice about eating a healthy diet, not smoking, and taking regular exercise. If so, it is important that you follow the advice you are given.
Can acebutolol cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with acebutolol. You will find a full list in the manufacturer's information leaflet supplied with your tablets/capsules. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common acebutolol side-effects (these affect around 1 in 10 people) What can I do if I experience this?
Feeling tired or dizzy, blurred vision Do not drive and do not use tools or machines until you feel more awake or able to see clearly
Feeling sick (nausea) or being sick (vomiting), diarrhoea Stick to simple meals - avoid rich and spicy foods. If you are not already doing so, try taking your doses after meals
Headache Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know
Cold hands or feet, feeling short of breath, disturbed sleep, mood changes, nightmares, skin rash If any of these become troublesome, speak with your doctor
Changes to your immune system Let your doctor know if you feel unwell or experience any unusual aches or pains
If you experience any other symptoms which you think may be due to acebutolol, speak with your doctor or pharmacist for further advice.

How to store acebutolol
Keep all medicines out of the reach and sight of children.
Store in a cool, dry place, away from direct heat and light.
Important information about all medicines
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

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Manufacturer's PIL, Sectral® 100 mg and 200 mg capsules; Sanofi, The electronic Medicines Compendium. Dated August 2014.

Manufacturer's PIL, Sectral® 400 mg Tablets; Sanofi, The electronic Medicines Compendium. Dated August 2014.

British National Formulary 74th Edition (Sep 2017); British Medical Association and Royal Pharmaceutical Society of Great Britain, London.

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